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home - Stomach - Gastric Polyps and Masses - Fundic Gland Polyps Written by Dr Sebastian Zeki

Fundic Gland Polyps

Clinical featuresRegression of fundic gland polyps has also reported with H.pylori infection.Presence of fundic gland polyps virtually excludes the presence of H.pylori infection. Fundic Gland Polyps FAP related fundic gland polyps80% of patients with FAP and attenuated variants of FAP have these polyps.They are equally common in males and females.They are multiple in >90 %.Consider FAP if fundal gland polyps are found and the patient is not taking PPIs.Dysplasia occurs in 20% polyps (assoc. with APC mutations in polyps). Sporadic fundal gland polyps These are more common in females.The polyps occur in middle age.Up to 40 % of patients have multiple polyps. PathologyThe polyps are composed of normal gastric corpus-type epithelium, arranged in a disorderly and/or micro-cystic configuration.Microcysts are characteristic, and are lined by any of the normal cell types found in the gastric corpus.The glandular compartment typically reveals distorted architecture with irregular gland buds, tortuous glands, or irregular stellate glandular configurations.Inflammation is usually minimal.Mild hyperplasia of the muscularis mucosa may occur in a pericystic configuration.The polyps probably arise from proliferation and differentiation of aberrantly located proliferative cells in the stem cell compartment of the corpus epithelium. Endoscopic FeaturesThey are small (0.1 to 0.8 cm), hyperemic, sessile, flat, nodular lesions that have a smooth surface contour.They occur exclusively in the gastric corpus.They are associated with PPIs. Written by Dr Sebastian Zeki

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