SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Small Bowel - Small Bowel Masses - Small bowel GIST Written by Dr Sebastian Zeki

Small bowel GIST

GIST (gastrointestinal stromal tumour-most common cause of thickened folds) Clinical Pres: Overt GI bleeding — 40 percent Abdominal mass — 40 percent Abdominal pain — 20 percent Sites:Stomach (50 percent) Small bowel (25 percent) Colon (10 percent),Omentum/mesentery (7 percent),Oesophagus (5 percent) Pathogenesis:: Interstitial cells of Cajal80% have ckit mutations, some of rest have PDGFRA mutations Work up: CT EUS and biopsy- C-kit stain on biopsy specimen PET- only for definitively unresectable or metastatic GISTs Endoscopy: broad base polyp with central ulceration 50% have intragastric component Malignant potential: size/mitotic count/miss sense mutation in C-kit gene Treatment: surgery with adjuvant treatment (high recurrence rate). Glivec if advanced If more than 2cm for resection

Related Stories

•Cocoa Seeds as a Phytobezoar Causing Intestinal Obstruction in a Ghanaian Child: A Case Report

•Disseminated Leiomyomatosis Following a Robotic-Assisted Myomectomy With Power Morcellation: A Case Report

•Multiple small bowel GIST as GI manifestation of neurofibromatosis type I: A case report

•An autopsy case of TFE3-rearranged PEComa-like neoplasm with systematic embolization involving the heart

•Abdominal lymphangioleiomyomatosis in a man presenting with gastrointestinal hemorrhage as the first manifestation: a case report