SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Small Bowel - Small Bowel Infections - Whipples Disease Written by Dr Sebastian Zeki

Whipples Disease

Clinical Features:Waisting and weight loss. Hyperpigmentation. Intestinal pain. Pleurisy. Pneumonitis. Lymphadenopathy. Encephalopathy. Steatorrhoea. Diarrhoea. Interstitial nephritis. Skin rashes. Eye inflammation. Athritis. Subcutaneous nodules. Endocarditis. I n t e s t i n a l e p i t h e l i u m Written by Dr Sebastian Zeki Whipple’s Disease DiagnosisD2 biopsies are PAS positive.PCR on CSF can give a positive result.PCR on blood is not good as it gives a high false +ve result. Behaves like MAC in AIDSTo grow, macrophages need deactivationTreat with IFNgamma in chronicityOrganism(35% in saliva and faeces) and IgG found (70%) in healthy volunteersMHC II downregulated in intestinal epithelial cells in infectees.This returns with treatment Low TH1Function Increased TH2 Function Low CD4/CD8 ratioMore matureIncreased activation T TreatmentThere is a high relapse rate with tetracycline.Initially give iv antibiotics known to penetrate blood brain barrier ( eg ceftriaxone/ penicillin G).After iv antibiotics give oral for 12 months (eg doxycycline/ TMP-SMX). Pathology....thought to be due to immune deficiency as evidenced by.....

Related Stories

Responses of intestinal organoids to infection by Mycobacterium avium resemble symptoms observed in Crohn's disease

Effect of humic acid supplementation on lamb gastrointestinal health and performance

Safety and outcomes of advanced IBD therapies in patients with HIV: a propensity-matched cohort analysis

Advanced therapies for inflammatory bowel disease associated with primary sclerosing cholangitis: a systematic review and meta-analysis

Impact of virulence genes and pathotypes of intestinal pathogenic Escherichia coli on gastrointestinal lesions in pre- and post-weaning piglets