SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Small Bowel - Small Bowel Infections - Whipples Disease Written by Dr Sebastian Zeki

Whipples Disease

Clinical Features:Waisting and weight loss. Hyperpigmentation. Intestinal pain. Pleurisy. Pneumonitis. Lymphadenopathy. Encephalopathy. Steatorrhoea. Diarrhoea. Interstitial nephritis. Skin rashes. Eye inflammation. Athritis. Subcutaneous nodules. Endocarditis. I n t e s t i n a l e p i t h e l i u m Written by Dr Sebastian Zeki Whipple’s Disease DiagnosisD2 biopsies are PAS positive.PCR on CSF can give a positive result.PCR on blood is not good as it gives a high false +ve result. Behaves like MAC in AIDSTo grow, macrophages need deactivationTreat with IFNgamma in chronicityOrganism(35% in saliva and faeces) and IgG found (70%) in healthy volunteersMHC II downregulated in intestinal epithelial cells in infectees.This returns with treatment Low TH1Function Increased TH2 Function Low CD4/CD8 ratioMore matureIncreased activation T TreatmentThere is a high relapse rate with tetracycline.Initially give iv antibiotics known to penetrate blood brain barrier ( eg ceftriaxone/ penicillin G).After iv antibiotics give oral for 12 months (eg doxycycline/ TMP-SMX). Pathology....thought to be due to immune deficiency as evidenced by.....

Related Stories

•Zinc in Inflammatory Bowel Disease: Biological Functions, Clinical Associations and Therapeutic Uncertainty

•Inhibiting the miR-511-3p/PTCH1/Hedgehog Axis Alleviates Sepsis-Induced Systemic Inflammation and Acute Liver Injury

•Deciphering the Pathogenicity of the PMS2 p.His701Gln Variant in a Family with Elderly-Onset Extracolonic Lynch Syndrome

•Extracellular matrix inhibits amino acid absorption mediated by Lactobacillus reuteri LR1 in ETEC-infected piglets

•Effects of dietary quercetin supplementation on growth performance and intestinal function in weaned pigs challenged by rotavirus