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home - Nutrition - Vitamins - Vitamin K Written by Dr Sebastian Zeki

Vitamin K

Micelles K Pancreatic enzymes Bile acids Absorption into enterocyte in distal small bowel Packaged into chylomicrons Bone formationCofactor in some bone mineralization proteins eg.osteocalcin Actions Vitamin K Carboxy-glutamate + Factors VII, IX, X Acitvated Factors VII, IX, X Vitamin K epoxide Vitamin k quinone Vitamin k quinol Reductase Reductase Warfarin Causes: 1. Antibiotics (by altering colonic flora)- can also inhibit vitamin K epoxide reductase enzyme in the liver 2. Prolonged starvation and TPN. 3. High doses of vitamin E and A antagonize vitamin K. 4. Newborn (immature liver, low vitamin K content of breast milk, a sterile gut, and poor placental transfer of vitamin K)- usually resolves in 1 month otherwise get hemorrhagic disease of the newborn. Clotting Protein K Dietary vitamin K1 (phylloquinones) Source: Green vegetablesRDA: 90 mcg/d women 120mcg/d menGut derived vitamin K2 - (menaquinone)Source: Gut micro-flora Vitamin K Sources Deficiency Written by Dr Sebastian Zeki

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