SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Nutrition - Vitamins - Vitamin E Written by Dr Sebastian Zeki

Vitamin E

Deficiency results inHaemolysisNeuromuscular disordersAtaxiaPeripheral neuropathy.Causes of deficiencyAny cause of fat malabsorption (pancreatic deficiency/ cholestasis)Rare genetic defects affecting vitamin E metab-lism or transport.Treatment: 200IU/ dExcess:Acute toxicity- not describedChronic toxicity- >400 IU/d associated with increased risk of hemorrhage and all-cause mortal-ity. Protein E Micelles E Pancreatic enzymes Bile acids Absorption into enterocyte in distal small bowel Packaged into chylomicrons Sources:Oils.Meat.Eggs.Leafy vegetables. Within hepatocytes, chylomicron remnants are broken down by lysosomes, and RRR-alpha-tocopherol is preferentially secreted into the bloodstream, packaged within VLDL molecules. The transport protein for alpha-tocopherol is named alpha-tocopherol transfer protein (A-TTP). Chylomicrons Vitamin E Broken Down Multiple remnants including apolipoproteins B and E, which contain retinol esters. Antioxidant May slow Alzheimer progression, tardive dyskinesia, and macular degeneration. May have a role in NASH treatment Vitamin E Mechanism of absorption Vitamin E compound types: 8 types (only 4 forms of Alphatocopherol are in humans- RRR-(the only forms in food, RSR-, RRS, and RSS- alpha-tocopherol- these last 3 are synthetic) Deficiency/ Excess/ Actions vitamin E Action: Written by Dr Sebastian Zeki

Related Stories

•When vitamin D modulates the microbiota for therapeutic purposes

•Genetic prediction of serum micronutrient levels and the risk of frailty: Evidence from a Mendelian randomization study

•A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway

•Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

•Chemical Characterization, Antioxidant Potential and Phenolic Profile of the Pulp and By-Products of Black puçá (Mouriri pusa), a Fruit from the Brazilian Cerrado region