•Beyond the Bowel: A Narrative Review Examining Bidirectional Mental Health Pathways Across Disorders of Gut-Brain Interaction and Inflammatory Bowel Disease
•Gastrodin alleviates acute colitis with comorbid anxiety- and depression-like behaviours rather than cognitive dysfunction by modulating gut microbiota and suppressing inflammation
•HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis
•Oral Astilbin Nanogels Modulate Senescence-Associated CD4+ T Cells and Promote Treg Induction in Aged Mice with Colitis
•Switching from Intravenous to Subcutaneous Infliximab in Children with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis